To solve this problem, we need to analyze the given statements:$\newline$Statement I: In prokaryotes, the positively charged DNA is held with some negatively charged proteins in a region called nucleoid.$\newline$Statement II: In eukaryotes, the negatively charged DNA is wrapped around the positively charged histone octamer to form nucleosome.$\newline$Let's break down each statement:$\newline \bullet$Statement I:$\newline$ - In prokaryotes, DNA is not associated with histones as in eukaryotes. Instead, it is associated with non-histone proteins.$\newline$ - The DNA in prokaryotes is negatively charged due to the phosphate backbone.$\newline$ - The proteins associated with DNA in prokaryotes are also negatively charged, not positively charged.$\newline$ - Therefore, Statement I is incorrect.$\newline \bullet$Statement II:$\newline$ - In eukaryotes, DNA is negatively charged due to the phosphate groups.$\newline$ - DNA wraps around histone proteins, which are positively charged due to the presence of basic amino acids like lysine and arginine.$\newline$ - This structure forms a nucleosome, which is the fundamental unit of chromatin.$\newline$ - Therefore, Statement II is true.$\newline$Based on the analysis, the correct answer is:$\newline$Option 4: Statement I is incorrect but Statement II is true.